The challenge of managing pulmonary hypertension in cancer patients

Dr Lenihan has been active in cardio-oncology and heart failure, for over 20 years. The main focus of these efforts have included hemodynamic assessments, angiogenic growth factor response, novel cardiac biomarkers as well as optimal methods to prevent or detect heart failure at the earliest stage possible in patients undergoing treatment for cancer. His current research projects include early phase clinical trials in cardio-oncology, heart failure and amyloidosis. He is the Principal Investigator of the PROTECT study looking at cardiac safety in patients undergoing proteasome inhibitor treatment for relapsed multiple myeloma and the recently completed PREDICT study, a large multicenter prospective study examining the role of cardiac biomarkers for the detection of cardiotoxicity during anthracycline based therapy. In addition, he is intimately involved in the latest treatment trials for cardiac amyloidosis. He was recently at Washington University in St Louis to enhance and expand the Cardio-Oncology Center of Excellence. He is at the forefront of concerted efforts to develop a viable Cardio-Oncology fellowship training program and continues to foster collaboration among a host of colleagues both regionally, nationally, and throughout the world. He is the current President of the International Cardio-Oncology Society (ICOS),www.IC-OS.org, which is an international professional association whose primary goal is to eliminate cardiac disease as a barrier to effective cancer therapy.

Joseph R. Carver, MD, FACC is a Board Certified cardiologist. He is the Founding Editor of the American Journal of Managed Care and was a Senior Corporate Medical Director at Aetna U.S. Healthcare from 1992-2001 where he was responsible for new program development and directed the National Medical Excellence Program. From 1999-2001, he was Co-chairperson of the New Jersey and Michigan Working Groups that established voluntary agreements among the insurers in those states to cover the routine costs of clinical trial participation for cancer patients. He is one of the Founding Editors of Cardio-oncology Journal. He currently is the Bernard Fishman Clinical Professor of Medicine at the Abramson Cancer Center of the University of Pennsylvania, the Chief Operating Officer of the Abramson Family Cancer Research Institute of the Abramson Cancer Center of the University of Pennsylvania and the Chief of Staff of the Abramson Cancer Center. He is the Director of the Thalheimer Cardio-oncology Center at the Abramson Cancer Center and his clinical practice is in the subspecialty of Cardio-oncology. He was the recipient of the IS Ravdin Master Clinician Award at Penn in 2012 and is one of the founding members of Penn Medicine’s Academy of Master Clinicians. He received the Thomas Force Award in 2020.

MD. Master in molecular biology. Specialist in radiotherapy and nuclear medicine. Staff pshysician at the department of Radiotherapy in Institute of Oncology Angel H. Roffo. Medical Advisor at IQVIA.

Dr. Gregorietti is currently Deputy Head of Heart Transplantation, and coordinates the Pulmonary Hypertension area of the Sacred Heart Sanatorium. She works in the area of Heart Failure and Pulmonary Hypertension at the Argentine Institute of Diagnosis and Treatment, and Hospital El Cruce. She received her medical degree from the Favaloro University of Buenos Aires Faculty of Medicine in 2001. Later, she specialized in Cardiology at the Fundación Favaloro Cardiology and Cardiovascular Surgery Service. The doctor herself completed her training in advanced cardiorespiratory failure, pulmonary hypertension and intrathoracic transplantation at the Fundacion Favaloro Transplant Services, Stanford University – California – USA. Dr. Gregorietti has participated and continues to participate in numerous national and international scientific societies, among which stand out: member of the Heart Failure Council of the Argentine Society of Cardiology, member of the heart failure and pulmonary hypertension committee of the Argentine Federation of Cardiology and chair in it the Cardio-Oncology committee, Argentine Transplant Society (in which she serves as deputy director of the cardiac transplant advisory committee of SAT); Sociedad de Cardiología de Buenos Aires (of which she is former president). She recently became a member of the Pulmonary Vascular Research Institute.