Session 8 - Thomas Force Memorial
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Chair: Dan Lenihan
Speaker: Bonnie Ky
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Date
- America/New_York
Bonnie Ky
I am a tenured Associate Professor of Medicine and Epidemiology and physician scientist at the...
Read MoreI am a tenured Associate Professor of Medicine and Epidemiology and physician scientist at the University of Pennsylvania. My fundamental goals are to gain insight into the underlying mechanisms and predictors of cancer therapy cardiotoxicity, and to translate this understanding to the clinical care of patients. I lead a highly active NIH-funded translational research program in cardio-oncology and am the PI of multiple investigator-initiated cohort studies and clinical trials focused on the study of the cardiotoxic effects of doxorubicin, trastuzumab, anti-angiogenic tyrosine kinase inhibitors, androgen deprivation therapy, and radiation therapy in breast, renal cell, prostate and lung cancers, and lymphoma patients. My programmatic objectives are to understand how we can improve cardiovascular outcomes in cancer patients by determining individual patient risk, through detailed phenotyping of clinical characteristics, the social determinants of health, biologic markers, and echocardiography-derived measures of myocardial mechanics and function. I also serve as the Director for the Penn Center for Quantitative Echocardiography and the Founding Director of the Penn Cardio-Oncology Translational Center of Excellence and have built a strong, multi-disciplinary collaborative network comprised of highly successful basic, translational, and clinical researchers. I am an invited member of many cardio-oncology expert consensus and research groups within the NIH, FDA, American Society of Clinical Oncology, American College of Cardiology, American Heart Association, and European Society of Cardiology focused on advancing our understanding of cardiovascular disease in the growing cancer population. I am the Inaugural Editor-in-Chief of JACC: CardioOncology, and successfully launched this important scientific and clinical resource. I have specialized expertise in cardio-oncology, epidemiology, the study of biomarkers, and imaging tools to understand cardiac remodeling, function, and risk prediction.
Show LessDaniel Lenihan
Dr Lenihan has been active in cardio-oncology and heart failure, for over 20 years. The main...
Read MoreDr Lenihan has been active in cardio-oncology and heart failure, for over 20 years. The main focus of these efforts have included hemodynamic assessments, angiogenic growth factor response, novel cardiac biomarkers as well as optimal methods to prevent or detect heart failure at the earliest stage possible in patients undergoing treatment for cancer. His current research projects include early phase clinical trials in cardio-oncology, heart failure and amyloidosis. He is the Principal Investigator of the PROTECT study looking at cardiac safety in patients undergoing proteasome inhibitor treatment for relapsed multiple myeloma and the recently completed PREDICT study, a large multicenter prospective study examining the role of cardiac biomarkers for the detection of cardiotoxicity during anthracycline based therapy. In addition, he is intimately involved in the latest treatment trials for cardiac amyloidosis. He was recently at Washington University in St Louis to enhance and expand the Cardio-Oncology Center of Excellence. He is at the forefront of concerted efforts to develop a viable Cardio-Oncology fellowship training program and continues to foster collaboration among a host of colleagues both regionally, nationally, and throughout the world. He is the current President of the International Cardio-Oncology Society (ICOS),www.IC-OS.org, which is an international professional association whose primary goal is to eliminate cardiac disease as a barrier to effective cancer therapy.
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