Philips
DEFINE-FLAIR & iFR SwedeHeart are multi-centre, prospective, international, randomized, blinded comparison of clinical outcomes and cost efficiencies of iFR (Instantaneous Wave-Free Ratio) and FFR (Fractional Flow Reserve) decision-making for physiological guided coronary revascularization.
Download material
DEFINE-FLAIR & iFR SwedeHeart 2-years trial results
Download the two-year outcomes of patients with revascularisation deferral based on FFR or iFR measurements
A pooled, patient level analysis of DEFINE FLAIR and iFR SWEDEHEART trials.
- 10 pages
- 8.4 MB
Featured Speakers
Javier Escaned
Prof Javier Escaned is Head of Interventional Cardiology Section at Hospital Clinico San Carlos...
Read More
Prof Javier Escaned is Head of Interventional Cardiology Section at Hospital Clinico San Carlos (Madrid, Spain). He trained as a cardiologist the United Kingdom before moving to the Thoraxcenter / Rotterdam (The Netherlands), where he obtained his PhD degree in 1994. With over 30 years of experience as interventionalist, he regularly serves as live case operator and educationalist in global events. He is author of over 500 PubMed indexed scientific articles (h-index 74) on topics that include complex PCI in multivessel disease, left main and chronic total occlusions. His track record in coronary physiology includes being investigator on pivotal FFR trials like DEFER (1998), collaborator with Justin Davies in the validation and clinical implementation of iFR (since 2010), and developer of new methods for the assessment of microvascular and non-obstructive coronary disease. Editorial work includes two large textbooks (“Coronary Stenosis. Imaging, Structure and Physiology” and “Physiological Assessment of Coronary Stenoses and the Microcirculation) and editorial board positions in scientific journals. Board positions in scientific societies include EuroPCR, EAPCI, EuroCTO and the ESC Working Group of Coronary Pathophysiology and Microcirculation. Additional interest incllude music and phylosophy. He is a recipient of the ESC Silver Medal and the 2022 ESC Andreas Gruentzig Award.
Show Less
Justin Davies
Dr Justin Davies is a clinical academic and consultant interventional cardiologist at the...
Read More
Dr Justin Davies is a clinical academic and consultant interventional cardiologist at the National Heart and Lung Institute, Imperial College London.
After training at Imperial College, he won a prestigious BHF research fellowship to study arterial haemodynamics. Since then he has continued to work on the development of mathematical algorithms to aid understanding of large artery physiology and to develop new tools to assess arterial disease.
The holder of several patents, he has published widely in the field of hypertension, coronary and large artery physiology and is the winner of many national and international awards. He has several international collaborations, and is the developer of iFR and the co-principal investigator of the ADVISE studies, the DEFINE-FLAIR, ORBITA and DEFINE-PCI studies. Justin also has an interest in renal denervation, and has lead the first-in-man studies to evaluate the safety of this technique to patients with chronic systolic heart failure (REACH studies).
Show Less
Matthias Götberg
Matthias Gotberg, MD, PhD works as an interventional cardiologist and Director of the Cardiac...
Read More
Matthias Gotberg, MD, PhD works as an interventional cardiologist and Director of the Cardiac Catheterization Lab at Skane University Hospital, Lund, Sweden. Dr. Gotberg has also been a member of the SCAAR steering committee since 2011. Dr. Gotberg has been principal investigator/investigator of numerous clinical trials, has authored or co-authored more than 70 publications in peer-reviewed journals, and is a recognized international expert within the field of coronary physiology and Transcatheter Aortic Valve Replacement.
Show Less
Patrick Serruys
Prof Patrick W. Serruys with respected h-index – 183 is a professor of Interventional...
Read More
Prof Patrick W. Serruys with respected h-index – 183 is a professor of Interventional Cardiology at the Interuniversity Cardiological Institute of the Netherlands (1988-1998) and Erasmus MC. Since 1980 he was a Director of the Clinical Research Program of the Catheterization Laboratory, Thorax Center at Erasmus University, and till April 1, 2014 (retirement date) the Head of the Interventional Department, Thorax Center, Erasmus MC (University Medical Center Rotterdam), Rotterdam, The Netherlands. Since April 2013, he holds the position of Professor of Cardiology in the Cardiovascular Science Division of the National Heart and Lung Institute (NHLI) at the Faculty of Medicine, within the Imperial College of Science, Technology and Medicine, London.He is a Fellow of the American College of Cardiology and a Fellow of the European Society of Cardiology and scientific council of the International College of Angiology.In 1996, he received the TCT Career Achievement Award and in 1997 he was awarded the Wenkebach Prize of the Dutch Heart Foundation. In 2000, he was awarded the Gruentzig Award of the European Society of Cardiology. In 2001, he held the Paul Dudley White Lecture at the American Heart Association in the USA. In 2004, he received the Andreas Gruentzig Award of the Swiss Society of Cardiology. In 2005, he held the 4th International Lecture at the AHA and Mikamo Lecture at the Japanese heart Association. In 2006, he received the highest award of the Clinical Council of the American Heart Association: the James Herrick Award. In 2007, he received the Arrigo Recordati International Prize (Italy) and the ICI Achievement Award (bestowed by the President of Israel – Shimon Perez). In 2008, he received the Einthoven Penning (Leiden). In 2009, he became Doctor Honoris Causa from the University of Athens. In 2011, he received the Lifetime Achievement Award, bestowed by the American College of Cardiology, in recognition of many years of service and invaluable contributions to the ACC. At the end of 2011, Prof Serruys received the Ray C. Fish Award, bestowed by the Texas Heart Institute, for outstanding achievement and contribution to cardiovascular medicine. In 2012, he received a Golden Medal of the European Society of Cardiology. In 2013, he became Doctor Honoris Causa from the Complutense University of Madrid. In 2016, he became Doctor Honoris Causa of the Melbourne University, Australia. Currently he is established Professor of Interventional Medicine and Innovation at the National University of Ireland, Galway.
Show Less
Manesh Patel
Manesh Patel is the Chief of the Division of Cardiology and the Division of Clinical...
Read More
Manesh Patel is the Chief of the Division of Cardiology and the Division of Clinical Pharmacology. His clinical interests include diagnostic and interventional coronary angiography, peripheral angiography and endovascular intervention. His is involved in several clinical trials involving patients with cardiovascular disease and in cardiac imaging. He is also the Chair of the American College of Cardiology Task Force for Appropriate Use Criteria for Cardiovascular Procedures and is Chair of the American Heart Association Diagnostic and Interventional Cath Committee.
Patel's interest in cardiac imaging, quality of care, cardiac devices is also evident in his research. His integration of these efforts into his roles at Duke was recognized in 2010 when he received the prestigious Duke Cardiology Fellowship Mentor Award. In 2011, Dr. Patel was named the endowed John Bush Simpson Assistant Professor of Cardiology. In 2013, Dr. Patel received the Robert M. Califf Faculty clinical research Award.
Currently, Dr. Patel is leading an effort to redesign the delivery of care to patients undergoing invasive catheterization procedures in the health system with a specific aim of measure and providing individualized, patient centered, innovative, and efficient care.
Show Less
Hitoshi Matsuo
Prof Hitoshi Matsuo is currently President of Gifu Heart Center,
and Clinical Visiting Professor...
Read More
Prof Hitoshi Matsuo is currently President of Gifu Heart Center,
and Clinical Visiting Professor of Cardiology in Aichi Medical University. He graduated from Jichi Medical School in 1986 and completed his residency in Gifu Prefectural Gifu Hospital. In 1987, during his residency period, Prof Hitoshi Matsuo spent one year at Johns Hopkins Medical Institutions in Baltimore as a research fellow in the Nuclear Medicine Department under the supervision of Professor Henry N Wagner Jr. From 1988, he returned to Gifu Prefectural Hospital where he dedicated clinical research work on physiology and interventional cardiology using nuclear medicine and pressure wires.
He received an annual award of Japanese Society of Nuclear Medicine in 1995 and the Clinical Research Award of Japanese Society of Interventional Cardiology in 2004. Thereafter, he moved to Toyohashi Heart Center as co-director of the catheterization laboratory from 2007 and returned to Gifu as the Director of Cardiovascular Medicine in 2009. Dr Matsuo now participates and contributes to many international multi-center trials including DEFINE-FLAIR, the international multicenter FFRCT registry (ADVANCE registry), 3V-FFR FRIENDS study and FAVOR2 Europe and Japan, DEFINE FLOW study.
Show Less
Allen Jeremias
Allen Jeremias, MD, MSc, is the Director of Interventional Cardiology Research and Associate...
Read More
Allen Jeremias, MD, MSc, is the Director of Interventional Cardiology Research and Associate Director of the Cardiac Catheterization Laboratory at St. Francis Hospital in Roslyn, New York. He is also a member of the Cardiovascular Research Foundation in New York City where he currently serves as the Director of the Physiology Core Laboratory. He completed his medical training at The Cleveland Clinic Foundation, Stanford University School of Medicine, and Harvard Medical School. He has been a high volume interventional cardiologist since 2006 and recognized as a Top Doctor in the New York Metro Area by Castle Connolly. Dr. Jeremias has significantly contributed to advancing the field of interventional cardiology and he is considered one of the foremost authorities in coronary physiology and intravascular imaging. He is a co-director of the annual St. Francis Intravascular Imaging and Coronary Physiology Workshop, teaching physicians around the world on “Precision Angioplasty”. Dr. Jeremias is presently engaged in a major global study that could change the path of treating clogged arteries. Known as the ILUMIEN IV trial, this major clinical study is evaluating Optical Coherence Tomography (OCT) to guide coronary stent placement. He is also the principal investigator of DEFINE PCI, an international study on assessing the improvement in blood flow after stent placement for severe coronary blockages.
Show Less
Javier Escaned
Prof Javier Escaned is Head of Interventional Cardiology Section at Hospital Clinico San Carlos...
Read MoreProf Javier Escaned is Head of Interventional Cardiology Section at Hospital Clinico San Carlos (Madrid, Spain). He trained as a cardiologist the United Kingdom before moving to the Thoraxcenter / Rotterdam (The Netherlands), where he obtained his PhD degree in 1994. With over 30 years of experience as interventionalist, he regularly serves as live case operator and educationalist in global events. He is author of over 500 PubMed indexed scientific articles (h-index 74) on topics that include complex PCI in multivessel disease, left main and chronic total occlusions. His track record in coronary physiology includes being investigator on pivotal FFR trials like DEFER (1998), collaborator with Justin Davies in the validation and clinical implementation of iFR (since 2010), and developer of new methods for the assessment of microvascular and non-obstructive coronary disease. Editorial work includes two large textbooks (“Coronary Stenosis. Imaging, Structure and Physiology” and “Physiological Assessment of Coronary Stenoses and the Microcirculation) and editorial board positions in scientific journals. Board positions in scientific societies include EuroPCR, EAPCI, EuroCTO and the ESC Working Group of Coronary Pathophysiology and Microcirculation. Additional interest incllude music and phylosophy. He is a recipient of the ESC Silver Medal and the 2022 ESC Andreas Gruentzig Award.
Show LessJustin Davies
Dr Justin Davies is a clinical academic and consultant interventional cardiologist at the...
Read MoreDr Justin Davies is a clinical academic and consultant interventional cardiologist at the National Heart and Lung Institute, Imperial College London. After training at Imperial College, he won a prestigious BHF research fellowship to study arterial haemodynamics. Since then he has continued to work on the development of mathematical algorithms to aid understanding of large artery physiology and to develop new tools to assess arterial disease. The holder of several patents, he has published widely in the field of hypertension, coronary and large artery physiology and is the winner of many national and international awards. He has several international collaborations, and is the developer of iFR and the co-principal investigator of the ADVISE studies, the DEFINE-FLAIR, ORBITA and DEFINE-PCI studies. Justin also has an interest in renal denervation, and has lead the first-in-man studies to evaluate the safety of this technique to patients with chronic systolic heart failure (REACH studies).
Show LessMatthias Götberg
Matthias Gotberg, MD, PhD works as an interventional cardiologist and Director of the Cardiac...
Read MoreMatthias Gotberg, MD, PhD works as an interventional cardiologist and Director of the Cardiac Catheterization Lab at Skane University Hospital, Lund, Sweden. Dr. Gotberg has also been a member of the SCAAR steering committee since 2011. Dr. Gotberg has been principal investigator/investigator of numerous clinical trials, has authored or co-authored more than 70 publications in peer-reviewed journals, and is a recognized international expert within the field of coronary physiology and Transcatheter Aortic Valve Replacement.
Show LessPatrick Serruys
Prof Patrick W. Serruys with respected h-index – 183 is a professor of Interventional...
Read MoreProf Patrick W. Serruys with respected h-index – 183 is a professor of Interventional Cardiology at the Interuniversity Cardiological Institute of the Netherlands (1988-1998) and Erasmus MC. Since 1980 he was a Director of the Clinical Research Program of the Catheterization Laboratory, Thorax Center at Erasmus University, and till April 1, 2014 (retirement date) the Head of the Interventional Department, Thorax Center, Erasmus MC (University Medical Center Rotterdam), Rotterdam, The Netherlands. Since April 2013, he holds the position of Professor of Cardiology in the Cardiovascular Science Division of the National Heart and Lung Institute (NHLI) at the Faculty of Medicine, within the Imperial College of Science, Technology and Medicine, London.He is a Fellow of the American College of Cardiology and a Fellow of the European Society of Cardiology and scientific council of the International College of Angiology.In 1996, he received the TCT Career Achievement Award and in 1997 he was awarded the Wenkebach Prize of the Dutch Heart Foundation. In 2000, he was awarded the Gruentzig Award of the European Society of Cardiology. In 2001, he held the Paul Dudley White Lecture at the American Heart Association in the USA. In 2004, he received the Andreas Gruentzig Award of the Swiss Society of Cardiology. In 2005, he held the 4th International Lecture at the AHA and Mikamo Lecture at the Japanese heart Association. In 2006, he received the highest award of the Clinical Council of the American Heart Association: the James Herrick Award. In 2007, he received the Arrigo Recordati International Prize (Italy) and the ICI Achievement Award (bestowed by the President of Israel – Shimon Perez). In 2008, he received the Einthoven Penning (Leiden). In 2009, he became Doctor Honoris Causa from the University of Athens. In 2011, he received the Lifetime Achievement Award, bestowed by the American College of Cardiology, in recognition of many years of service and invaluable contributions to the ACC. At the end of 2011, Prof Serruys received the Ray C. Fish Award, bestowed by the Texas Heart Institute, for outstanding achievement and contribution to cardiovascular medicine. In 2012, he received a Golden Medal of the European Society of Cardiology. In 2013, he became Doctor Honoris Causa from the Complutense University of Madrid. In 2016, he became Doctor Honoris Causa of the Melbourne University, Australia. Currently he is established Professor of Interventional Medicine and Innovation at the National University of Ireland, Galway.
Show LessManesh Patel
Manesh Patel is the Chief of the Division of Cardiology and the Division of Clinical...
Read MoreManesh Patel is the Chief of the Division of Cardiology and the Division of Clinical Pharmacology. His clinical interests include diagnostic and interventional coronary angiography, peripheral angiography and endovascular intervention. His is involved in several clinical trials involving patients with cardiovascular disease and in cardiac imaging. He is also the Chair of the American College of Cardiology Task Force for Appropriate Use Criteria for Cardiovascular Procedures and is Chair of the American Heart Association Diagnostic and Interventional Cath Committee. Patel's interest in cardiac imaging, quality of care, cardiac devices is also evident in his research. His integration of these efforts into his roles at Duke was recognized in 2010 when he received the prestigious Duke Cardiology Fellowship Mentor Award. In 2011, Dr. Patel was named the endowed John Bush Simpson Assistant Professor of Cardiology. In 2013, Dr. Patel received the Robert M. Califf Faculty clinical research Award. Currently, Dr. Patel is leading an effort to redesign the delivery of care to patients undergoing invasive catheterization procedures in the health system with a specific aim of measure and providing individualized, patient centered, innovative, and efficient care.
Show LessHitoshi Matsuo
Prof Hitoshi Matsuo is currently President of Gifu Heart Center, and Clinical Visiting Professor...
Read MoreProf Hitoshi Matsuo is currently President of Gifu Heart Center, and Clinical Visiting Professor of Cardiology in Aichi Medical University. He graduated from Jichi Medical School in 1986 and completed his residency in Gifu Prefectural Gifu Hospital. In 1987, during his residency period, Prof Hitoshi Matsuo spent one year at Johns Hopkins Medical Institutions in Baltimore as a research fellow in the Nuclear Medicine Department under the supervision of Professor Henry N Wagner Jr. From 1988, he returned to Gifu Prefectural Hospital where he dedicated clinical research work on physiology and interventional cardiology using nuclear medicine and pressure wires. He received an annual award of Japanese Society of Nuclear Medicine in 1995 and the Clinical Research Award of Japanese Society of Interventional Cardiology in 2004. Thereafter, he moved to Toyohashi Heart Center as co-director of the catheterization laboratory from 2007 and returned to Gifu as the Director of Cardiovascular Medicine in 2009. Dr Matsuo now participates and contributes to many international multi-center trials including DEFINE-FLAIR, the international multicenter FFRCT registry (ADVANCE registry), 3V-FFR FRIENDS study and FAVOR2 Europe and Japan, DEFINE FLOW study.
Show LessAllen Jeremias
Allen Jeremias, MD, MSc, is the Director of Interventional Cardiology Research and Associate...
Read MoreAllen Jeremias, MD, MSc, is the Director of Interventional Cardiology Research and Associate Director of the Cardiac Catheterization Laboratory at St. Francis Hospital in Roslyn, New York. He is also a member of the Cardiovascular Research Foundation in New York City where he currently serves as the Director of the Physiology Core Laboratory. He completed his medical training at The Cleveland Clinic Foundation, Stanford University School of Medicine, and Harvard Medical School. He has been a high volume interventional cardiologist since 2006 and recognized as a Top Doctor in the New York Metro Area by Castle Connolly. Dr. Jeremias has significantly contributed to advancing the field of interventional cardiology and he is considered one of the foremost authorities in coronary physiology and intravascular imaging. He is a co-director of the annual St. Francis Intravascular Imaging and Coronary Physiology Workshop, teaching physicians around the world on “Precision Angioplasty”. Dr. Jeremias is presently engaged in a major global study that could change the path of treating clogged arteries. Known as the ILUMIEN IV trial, this major clinical study is evaluating Optical Coherence Tomography (OCT) to guide coronary stent placement. He is also the principal investigator of DEFINE PCI, an international study on assessing the improvement in blood flow after stent placement for severe coronary blockages.
Show LessHighlighted Event