The clinical interpretation of the DEFINE FLOW study
Updates into the latest updates in coronary interventions
Dr Jan Piek is a clinical academic and interventional cardiologist at the Amsterdam University Medical Centers at the...
Dr Jan Piek is a clinical academic and interventional cardiologist at the Amsterdam University Medical Centers at the University of Amsterdam. At the moment, he has a full-time position as a professor of clinical cardiology at the AMC Heart Center in Amsterdam. His particular interest is interventional cardiology in which field he has been active for almost 30 years. In his academic position, he has supervised approximately 55 PhD students on the theme diagnosis and treatment of coronary artery disease. The topic of his research work focusses on translational aspects of coronary atherosclerosis. This started in the area of arteriogenesis after the completion of his thesis in 1992 followed by a close collaboration with the research group of Prof. Wolfgang Schaper from Bad Nauheim in Germany. In the same period, he started pioneering with the company Cardiometris, Mountain View, Ca, USA, that finally led the development of guidewires, equipped with pressure and Doppler sensors, as a technical refinement for guidance of coronary interventions. Moreover, subsequent studies performed on reperfusion injury with dedicated centers in the US and Germany, provided novel insights into the inflammatory response following acute myocardial infarction. His pioneering work on coronary hemodynamics led to creation of an international network of specialized centers. The DEFINE FLOW study involves a collaboration between Texas Heart Institute and the Amsterdam University Medical Center on combined pressure and flow measurements and was conducted in 12 sites worldwide. The last three years, he has worked as the editor in chief of the Netherlands Heart Journal.