Live case demonstration: Co-registration iFR Transmission from Hospital Clinico San Carlos, Madrid

Prof Andrew Sharp qualified from Edinburgh Medical School in 1998 and is Professor of Cardiology at the University Hospital of Wales and Cardiff University in the U.K. He conducted his early training at the Royal Infirmary of Edinburgh, before moving to London for his senior clinical training. He completed the prestigious Milan-Imperial Interventional Cardiology Fellowship programme, having spent a year in San Raffaele and Columbus Hospitals, Milan, Italy, under the tutelage of Professor Antonio Colombo. He also spent three years training in interventional cardiology at Imperial College Hospitals in London. Prof Sharp was awarded an MD postgraduate research degree from the University of Edinburgh for his work on the hypertensive heart and his research interests include intracoronary imaging and physiology. as well as the use of device-based treatments for hypertension and pulmonary embolism.

Carlo Di Mario is Professor of Cardiology at the University of Florence and Director of the Structural 
Interventional Cardiology Division of the University Hospital Careggi, Florence, Italy. Previous posts included 15 years as Professor of Clinical Cardiology at Imperial College of Sciences, Medicine & Technology, London and Consultant Cardiologist at the Royal Brompton Hospital. Despite his teaching, research and administrative commitments, he maintains an active clinical involvement performing more than 100 PCI per year with special interest in the treatment of calcified lesions, chronic total occlusions, bifurcations, and diffuse disease. He is a regular TAVI operator and certified implanter for the Medtronic Evolut R and Edwards Sapien 3 transcatheter aortic valves. He participated in more than 160 MitraClip implantations in London and Florence and has recently started direct annuloplasty with the CardioBand. Professor Di Mario pioneered the use of intracoronary Doppler, pressure measurement, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy. He was PI of the OPTICUS trial, failing to demonstrate superiority of IVUS guided stenting, and of the Lipid Rich Plaque study, due to report at TCT 2018. He was Principal Investigator of the DESTINI trial, using Doppler CRF to identify lesions in need of stenting, and of the CARESS in AMI trial, a large multicentre trial showing that patients who receive fibrinolytic therapy for ST-elevation myocardial infarction benefit from early angioplasty. This trial and a subsequent meta-analysis have led to a change in the European Society of Cardiology and AHA/ACC Guidelines for treatment of STEMI patients. He cooperated with Dr Davies to the validation of iFR to assess lesion severity and discriminate the contribution of individual lesions, and with Dr Lyon in the intracoronary delivery of SERCA-2 genes via adenoviral vectors in the CUPID2 trial.

Prof Javier Escaned is Head of Section (Interventional Cardiology Section) at Hospital Clinico San Carlos / Complutense University (Madrid, Spain). He trained in the United Kingdom as Specialist in Cardiology and obtained his PhD in The Netherlands. Author of >600 indexed scientific articles on interventional cardiology, imaging and physiology (h-index 74) and over 30 years of experience as PCI operator, he regularly lectures and performs live cases at major scientific and educational meetings. He is a recipient of the European Society of Cardiology (ESC) Silver Medal and the Andreas Grüntzig Award for his contributions to the fiedl fo Interventional Cardiology. Main areas of expertise include complex PCI, intracoronary diagnostics and functional coronary angiography. His track record in coronary physiology comprises being investigator on pioneer FFR trials like DEFER (1998), collaborator with Justin Davies in the validation and clinical implementation of iFR, and developer of new tools for the assessment of coronary microcirculation. Editorial roles include Deputy Editor EHJ, Advisory Editor Eurointervention, editor of the textbooks “Coronary Stenosis: Imaging, Structure and Physiology” and “Physiological Assessment of Coronary Stenoses and the Microcirculation". Recent board positions include EAPCI board / Education Committee Chair, ESC WG Coronary Pathophysiology and Microcirculation, EuroCTO Board. Recent trials as Principal Investigator include ADVISE II, DEFINE FLAIR, SYNTAX II, PIONEER IV, Cerebral-Coronary-Connection (C3), DCR4Contrast, INOCA LongCovid and AID ANGIO. Additional interests are philosophy and music.

Dr Justin Davies is a honorary 
interventional cardiologist at Hammersmith Hospital, Imperial College NHS Trust, London. After training at Imperial College, he won a prestigious BHF research fellowship to study arterial haemodynamics. Since then he has continued to
work on the development of mathematical algorithms to aid understanding of large artery physiology and to develop new tools to assess arterial disease. The holder of several patents,
he has published widely in the field of hypertension, coronary and large artery physiology and is the winner of many national and international awards. He has several international collaborations, and is the developer of iFR and the co-principal investigator of the ADVISE studies, the DEFINE-FLAIR, ORBITA and DEFINE-PCI studies. Justin also has an interest in renal denervation, and has lead the first-in-man studies to evaluate the safety of this technique to patients with chronic systolic heart failure (REACH studies).

Dr Nieves Gonzalo is a Consultant Interventional Cardiologist at Clinico San Carlos University Hospital, Madrid, Spain. She obtained her Specialist Certification in Cardiology after training at Clinico San Carlos University Hospital in Madrid. Subsequently, she underwent a research fellowship at Thoraxcenter, Erasmus University Rotterdam (The Netherlands) focused mainly in intracoronary imaging and bioabsorbable stents. In 2010 she obtained her PhD with the thesis “Optical coherence tomography for the assessment of coronary atherosclerosis and vessel response after stent implantation”. Her track record includes over 170 articles indexed in PubMed, as well as book chapters in Interventional Cardiology textbooks. Recent research projects as principal investigator includes studies about neoatherosclerosis, vessel injury and healing after stent implantation and patterns of calcification in coronary disease. Dr Gonzalo is a dedicated educationalist with involvement in many areas of complex PCI. In 2022, Dr Gonzalo was appointed as a course director for EuroPCR, she also serves as a deputy editor of EuroIntervention, and as a co-chair of the European Association of Percutaneous Cardiovascular Interventions (EAPCI) Scientific Documents and Initiatives Committee.

Sa’ar Minha MD is a professor of cardiology at Tel-Aviv University, Israel, and the director of interventional cardiology at Shamir Medical Center, Be’er Yaakov in Israel- one of the largest government-owned hospitals in the country. He also serves as the secretary of the interventional cardiology working group under the Israel Heart Society. Prof. Minha earned his MD degree from Tel-Aviv University in Israel and completed an internal medicine residency and cardiology fellowship at Shamir Medical Center. His interventional cardiology fellowship was completed in 2014 at the Washington Hospital Center, affiliated with Georgetown University, Washington DC under Prof. Ron Waksman, Prof. Gus Pichard, and Prof. Lowell Satler. Prof Minha is an active speaker and an invited faculty for major international cardiology conferences and the co-author of over 110 original research publications. His main interests are complex coronary interventions combining physiology and imaging for optimizing results and outcomes, interventions for pulmonary embolism, renal denervation for treating hypertension, and interventions under mechanical circulatory support.

Dr Sunao Nakamura is one of the most experienced interventional cardiologist Japan. He had performed more than 25,000 cases of PCI and 10,000 cases of chronic total occlusion (CTO) which is a biggest numbers in the world. He has a very unique background as a researcher; studying about cellular electro-physiology for 6 years and clinical sciences for 4 years in his younger days. After that he suddenly changed his main field of cardiology; Interventional cardiology with respect of Prof. Shigeru Saito ; who was active in the leadership position in Asia region, Dr. Nakamura worked disseminate PCI in Asia from his age early 30s and experienced living a half of the year in foreign countries. As a result of through these actives over the years, he has built good relations with many doctors who share the same goals all over the world. His motto is that patients around the world should be saved not only we think about the patients who come here to our hospital by sharing each other’s skills and knowledge. He is also fully engaged in the leading edge of clinical activities and researches, and at his New Tokyo Hospital, many clinical and basic studies are conducted every year, and about 30 papers are published annually. Especially in close relation with Professor Antonio Colombo, Italy, our young doctors who received his guidance are active not only as a physician but also as a medical scientist in New Tokyo Hospital. His dream is to make the world's leading heart center capable of medical research from basic to clinical.