Bonnie Ky

I am a tenured Associate Professor of Medicine and Epidemiology and physician scientist at the University of Pennsylvania. My fundamental goals are to gain insight into the underlying mechanisms and predictors of cancer therapy cardiotoxicity, and to translate this understanding to the clinical care of patients. I lead a highly active NIH-funded translational research program in cardio-oncology and am the PI of multiple investigator-initiated cohort studies and clinical trials focused on the study of the cardiotoxic effects of doxorubicin, trastuzumab, anti-angiogenic tyrosine kinase inhibitors, androgen deprivation therapy, and radiation therapy in breast, renal cell, prostate and lung cancers, and lymphoma patients. My programmatic objectives are to understand how we can improve cardiovascular outcomes in cancer patients by determining individual patient risk, through detailed phenotyping of clinical characteristics, the social determinants of health, biologic markers, and echocardiography-derived measures of myocardial mechanics and function. I also serve as the Director for the Penn Center for Quantitative Echocardiography and the Founding Director of the Penn Cardio-Oncology Translational Center of Excellence and have built a strong, multi-disciplinary collaborative network comprised of highly successful basic, translational, and clinical researchers. I am an invited member of many cardio-oncology expert consensus and research groups within the NIH, FDA, American Society of Clinical Oncology, American College of Cardiology, American Heart Association, and European Society of Cardiology focused on advancing our understanding of cardiovascular disease in the growing cancer population. I am the Inaugural Editor-in-Chief of JACC: CardioOncology, and successfully launched this important scientific and clinical resource. I have specialized expertise in cardio-oncology, epidemiology, the study of biomarkers, and imaging tools to understand cardiac remodeling, function, and risk prediction.