DEFER, FAME, and FAME II – What They Didn’t Answer - Dr. Ricardo Petraco

Summary

Speaker: Dr Ricardo Petraco, Imperial College Healthcare NHS Trust, London

Ricardo Petraco discusses the remaining knowledge gaps in the clinical trial data in coronary physiology, and describes how new studies may help to answer the outstanding questions.

Key learning points:

• 1. Limitations of current clinical trials
• 2. The effects of patient distribution on clinical trial results
• 3. Coronary physiology is a continuous variable not a dichotomous measure
• 4. FFR of 0.67 is strongly predictive of coronary disease
• 5. iFR Clinical outcome trials Define Flair and iFR SwedeHeart